{"schema":"sb.node.v1","id":"sb:e/feacdd1ea8f1fb676966d5e2","kind":"entity","label":{"text":"kras-mutant","locale":"en"},"identity":{"anchor":"label:en:kras-mutant","strength":"label"},"asOf":{"knowledgeCutoff":"2026-11-10T23:26:12.528504+00:00","releaseId":"sb-8792b91ece33","snapshot":"deploy cb03188cd71ab9aaafd7516efad4097bf188509c"},"lens":{"kind":"public"},"build":{"plane":"projected","builtFrom":["entity_graph.slim.json","entity_receipts (deploy asset)","event_graph.json","truth_records (deploy asset)","corroborated_record.json"],"rule":"node-projection.entity@v1"},"standing":{"evidence":{"supporting":67,"separatePublishers":39,"basis":"documents that mention the subject and the outlets that carried them; a mention is evidence the referent is in use, not evidence about any claim","receiptsOnTopic":{"state":"measured","share":0.761,"named":51,"of":67,"basis":"documents whose own title or summary lead names the subject, over every counted document that mentions it anywhere (the entity graph's measurement); receipts are drawn only from rows whose own title or URL names the subject (the entity graph's subject gate)"}},"admission":{"state":"canonical","kind":"receipted","kindBasis":"receipt-on-file","reason":"entity graph provenance 'curated'; promoted from the corpus by the machine rule; the promotion receipt (bars, evidence, snapshot) is on file but its contents are not yet served","policy":"promotion (receipt on file; contents not yet served)","admittedOn":"2026-11-05"},"disposition":{"state":"served","reason":"public record"},"validity":{"from":"2026-03-11","to":"2026-11-09","basis":"first and last day we saw it mentioned; not the subject's own lifetime"},"measurement":{"state":"partial","share":0.104,"blind":["10% of mentions say something specific about it; the rest only name it"]}},"dimensions":{"domains":["oncology"],"activeDays":51,"assertions":{}},"up":[],"upNote":"An entity is a root: it is contained by nothing. Pan out by following R.","children":{"count":7,"byKind":{"observation":7},"withheld":{"state":"withheld","count":5,"reason":"5 receipts withheld: no source link (the same rule the topic record applies)"},"items":[{"id":"sb:o/fcdc1732f8fae063f84e3763","kind":"observation","label":"Parasites Hosts Dis · 2026-11-06 · Toxoplasma gondii GRA16-induced apoptosis in KRAS-mutant colorectal cancer cells is linked to coordinated p53 and PP2A-B55 signaling.","url":"https://doi.org/10.3347/PHD.26050","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/4708c8d51cdf0517b7614b9e","kind":"observation","label":"Cancer Med · 2026-10-30 · Divergent Roles of PIK3C3 in KRAS-Wild-Type and KRAS-Mutant Advanced Colorectal Cancer: Implications for 5-Fluorouracil Sensitivity and Prognosis.","url":"https://doi.org/10.1002/cam4.72434","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/0828ac4cc2ba03e057202ea1","kind":"observation","label":"Sci Adv · 2026-10-23 · CASTOR1 functional inactivation drives KRAS-mutant NSCLC and therapy resistance by a noncanonical mechanism of tumor suppression.","url":"https://doi.org/10.1126/sciadv.aeb9836","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/f47fded6dbbed2c5a7971941","kind":"observation","label":"J Med Chem · 2026-10-22 · Discovery and Optimization of Isoform Selective ULK1 Degraders to Enhance Antitumor Activity in KRAS-Mutant Cancer.","url":"https://doi.org/10.1021/acs.jmedchem.6c01340","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/4232fccb0015b38f57188dd5","kind":"observation","label":"Front Oncol · 2026-10-16 · Comparative efficacy of fruquintinib, regorafenib or TAS-102 in patients with KRAS-mutant metastatic colorectal cancer: a systematic review and network meta-analysis.","url":"https://doi.org/10.3389/fonc.2026.1948508","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/80f9042181e35b44d941e8d1","kind":"observation","label":"Phytomedicine · 2026-10-04 · Zuojin Wan reverses cetuximab resistance in KRAS-mutant colorectal cancer via the NRF2-GCH1/CoQ and DHODH/CoQ axes.","url":"https://doi.org/10.1016/j.phymed.2026.158852","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}},{"id":"sb:o/1aa361f786b2059a11ec0098","kind":"observation","label":"Eur J Med Chem · 2026-09-27 · Design, synthesis, and structural optimization of novel pan-KRAS degrader for the treatment of KRAS-mutant pancreatic cancer","url":"https://doi.org/10.1016/j.ejmech.2026.119362","match":{"surface":"title","basis":"admitted by the entity graph's subject gate (title or URL); the headline names the subject as whole words (the door's on-topic test)"}}],"cursor":null,"order":"newest first; we keep the 7 newest receipts for this entity whose own title or URL (the entity graph's subject gate) names it; each says which in match. Its other observations are counted in standing.evidence.supporting but are not addressable in v1"},"relations":{"count":5,"byKind":{"co-mentioned":5},"items":[{"kind":"relation","label":"co-mentioned with kras (67 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/01eda8a71d27fc6bc646c93f"},{"kind":"relation","label":"co-mentioned with colorectal cancer (31 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/e83f11e9d2a47b87e157ca15"},{"kind":"relation","label":"co-mentioned with lung cancer (17 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/62456a9617f494787f94e37d"},{"kind":"relation","label":"co-mentioned with cancer cells (10 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/cc5acb3b87e438e4bf435aa6"},{"kind":"relation","label":"co-mentioned with fda (8 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/81590517b551c82bf501e4e5"}],"cursor":null,"order":"situations first, then claims (the subject's own maintained record, then site-wide corroborated clusters; each label ends with its standing), then co-mentions by shared documents, descending. Co-mentions are the ten strongest the entity graph keeps per entity"},"edge":{"state":"continues"},"links":{"rest":"/api/v1/node/e/feacdd1ea8f1fb676966d5e2","mcp":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}","page":"/entity/kras-mutant/"},"limits":{"levelsPerCall":1,"pageSize":10,"maxPageSize":50,"membersMax":50,"statement":"One level per call: depth is 1 and only 1, and there is no whole-graph dump. pageSize 1-50 (default 10); a page limit is a cursor, never an edge. Members are listed up to 50. At most 60 traverse calls a minute per caller (runaway-loop protection, not a meter). One knowledge cutoff is served: the deploy's."},"actions":[{"verb":"unfold","lit":true,"effect":"read","layer":"free-record","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\",\"level\":\"children\"}"},{"verb":"fold","lit":true,"effect":"read","layer":"free-record","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}"},{"verb":"panOut","lit":false,"effect":"read","layer":"free-record","reason":"An entity is a root: it is contained by nothing. Pan out by following R."},{"verb":"follow","lit":true,"effect":"read","layer":"free-record","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\",\"level\":\"relations\"}"},{"verb":"receipts","lit":false,"effect":"read","layer":"free-record","reason":"receipts are the observations below this node; unfold to reach them"},{"verb":"edge","lit":true,"effect":"read","layer":"free-record","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}"},{"verb":"asOf","lit":false,"effect":"read","layer":"free-record","reason":"v1 serves one knowledge cutoff, this deploy's; walking an earlier cutoff needs retained history, which v1 does not keep"},{"verb":"switchObserver","lit":false,"effect":"read","layer":"free-record","reason":"the public record is the same for every observer; traversal through a Watch's lens is not served in v1"},{"verb":"readOriginal","lit":false,"effect":"read","layer":"free-record","reason":"no translation is applied on this node; every label is the source's own text"},{"verb":"save","lit":false,"effect":"watch-declaration","layer":"watch","reason":"saving applies to a configured Watch; configure one around this node first (free), then save it"},{"verb":"deliver","lit":false,"effect":"watch-declaration","layer":"watch","reason":"delivery applies to a saved Watch"},{"verb":"format","lit":false,"effect":"watch-declaration","layer":"watch","reason":"output format applies to a saved Watch"},{"verb":"deltaR","lit":false,"effect":"read","layer":"watch","reason":"Delta R needs a saved Watch with a previous reading"},{"verb":"read","lit":false,"effect":"read","layer":"one-time-read","reason":"one-time Reads are not offered through this door; use ask"}]}